Happy Three Years!

I can’t believe it but Pilates On Demand has been running for three years. Thank you so much for being part of this journey. My mission still remains the same - provide Pilates classes you can take with you anywhere that will help you reset while we contribute to organizations that are making a difference in our communities. It might not be fancy, but your workouts don’t need to be. Working out should make you feel good, so I hope you keep taking small steps to do what makes you feel good and  surround yourself with people who make you feel good.


Wishing you all the good now and always.

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This month, 20% of our proceeds goes to Every Cure.


In 2010, Every Cure’s founder Dr. David Fajgenbaum was a third-year medical student when he became critically ill with Castleman disease. He spent months hospitalized in critical condition and nearly died five times. David was told there were no more options for his disease and waiting for a new treatment - requiring billions of research dollars and 10-15 years - was not a possibility. Repurposing an existing drug was his only hope. David launched an initiative to find treatments to save his life and the lives of others with CD. He and his team discovered an overactive pathway in his blood and tested a 25-year old drug called sirolimus that was approved as an immunosuppressant after kidney transplants but had never been used for CD, to block that pathway. As a result, David has been in remission for more than 11 years.


In the last 10 years, Dr. Fajgenbaum’s team has advanced 14 repurposed drugs for multiple diseases and they are scaling this work through Every Cure. Every cure was founded to ensure that patients don’t suffer while potential treatments hid in plain sight. For the first time, AI can leapfrog over repurposing barriers, unlocking cures at a fraction of cost and time. Their AI approach enables rapid and systematic analysis of the world’s biomedical knowledge. While traditional research would take years to investigate all diseases, their approach looks across all 18k diseases and 4k drugs, quantifying the strength of 75M drug-disease matches within days. Their team assesses the highest possible matches, generates evidence about effectiveness through research and validation and disseminates successes in partnership with patient organizations, democratizing medical insights and and reducing health inequities worldwide.


Together, with partners in medicine, pharma, tech and philanthropy, they are building out a comprehensive, open-source database of drug-repurposing opportunities. They are deeply passionate about uncovering repurposed drugs for patients who are suffering while there is a drug sitting at their neighborhood pharmacy, and want to scale drug repurposing to help each and every patient who may benefit by using an already existing drug.


To learn more about their work, visit their website: https://everycure.org/

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